The Best Medicine For Anxiety Disorders SSRIs and SNRIs such as citalopram escitalopram, fluoxetine (Prozac) Venlafaxine, citalopram, and duloxetine are first-line treatments for anxiety disorders. Exercise and psychotherapy are also essential for those suffering from anxiety. Some doctors prescribe antihistamines such as hydroxyzine (Atarax or Vistaril). They aid in blocking